The summer is over and the busy autumn has begun.
While the R&D cooperations are going on as usual, we will hear a lot from politicians about the future of Europe. After the French President Macron and EU Commission President Juncker have more or less concretely outlined their respective proposals, it will depend first of all on the difficult formation of a government in Germany, when reforms of the confusing structure of the European Union will take place. After all, there is debate and argument everywhere - in many other parts of the world there is shooting instead. Happy Europe so far!
The autumn issue of the European Biotechnology Magazine will be published next week and sent to all members. The major topics are big data and cancer, extremophiles and energy, food produced from insects and trends in biomanufacturing. Be curious! And don’t forget to refer to our EBN page with news from our corporate members.
Something else: Market demand is increasing for cosmetics that are produced with natural enzyme-based conversions rather than chemical processes. With the OPTIBIOCAT project, European researchers launched a major initiative that is sifting through the genomes of fungi and bacteria and evolved enzymatic variants for appropriate biocatalysts. Its final conference Mining enzymes for green products takes place on 7.11.2017 from 09:00 – 13:30 at the ECOMONDO in Rimini, Italy. More information at www.optibiocat.eu
20-06-2017 - The trend is your friend.
The magazine “Scientific American“, together with experts from the World Economic Forum, has presented a list of the ten most important technologies for the coming years. With liquid biopsies, artificial photosynthesis, a human cell atlas, genomic vaccines composed of DNA or RNA, and “green" architecture, half of list is based on the life sciences. Alternative drinking water production, computer-assisted image recognition and IT-supported agriculture should also have a direct impact on our sector. Hydrogen fuel cells and quantum computers complete the optimistic scenario: 10 disruptive innovations that are on the verge of making a difference to the planet’s future.
19-04-2017 - This month, Katja and Laura from EBN’s ENABLE team presented fresh news.
The ENABLE project was launched within IMI's 'New Drugs for Bad Bugs' (ND4BB) programme and works to advance the development of potential antibiotics against Gram-negative bacteria, such as Escherichia coli. The goal of the project is to develop attractive antimicrobial candidates for testing in the clinic, bringing the possibility of new antibiotics to treat Gram-negative infections one step closer to patients.
Topically the consortium presents the key events that happened within the project over the past months, introduces its new partners, including the new project coordinator from GSK, and gives insights into selected programmes. Furthermore, the Swiss start-up company Juvabis talks about its Apramycin programme, which is currently undergoing preclinical evaluation to expand initial proof-of-concept in animals to various disease models. If you are interested, you can find the ENABLE news here.
21-03-2017 - Here are the results of our members‘ survey. We had a very good response with a lot of individual proposals for the future development of the network.
- Our monthly newsletter is rated essential by 55%, nice to have by 44%, and unnecessary by 1%.
- Cooperation with major European conferences and trade fairs, combined with a discount for EBN members, is essential for 52%, nice to have for 41% and unnecessary for 7%.
- The free subscription of the „European Biotechnology Magazine“ is considered essential by 70%, another 29% voted for nice to have, and 1% for unnecessary.
- An EBN office in Brussels with contact to the EU consider 49% as essential, 42% as nice to have and 9% consider it unnecessary.
- For an annual „European Biotechnology Network Convention“ 42% voted with essential, 49% found it nice to have and 8% considered it unnecessary.
The many individual proposals for future activities of the network were very interesting. Our thanks to all the members for their participation. The following wishes were mentioned frequently:
- promoting of SMEs
- creating links between academia and industry
- workshops about different topics, e.g. clinical development, enzymes, software development etc.
- more virtual networking opportunities, online forum for members
- a directory of members
- information and activities about funding opportunities and consortium building
- a free company database
It is easy to understand that there is a great need for information and for opportunities for increased interaction between our members. We see two main difficulties:
- Frequently desired services such as funding opportunities and consortium building are both time-consuming and personnel-intensive and therefore hardly affordable for a network whose individual membership is free of charge.
- Data protection obliges us to treat the data of our members confidentially, in order to protect them from undesirable advertising. Even a passing on to the members themselves seems hardly possible at the moment, because advertisers can of course log in as a free member themselves and thus could gain free access to the data treasure.
We will review all proposals for their chance of implementation within the framework of our possibilities and will report the results to you soon.
24.02.2017 - EBN was Supporting Partner of the "10th Berlin Conference on Life Sciences – Novel Antimicrobials“. Since the withdrawal of Big Pharma in the late ’80s, the antibiotic research market has dried up. Supported by public funds, European small and medium sized enterprises (SMEs) create new alliances to reanimate the market.
Health care payers see a growing need to fight emerging antimicrobial resistances (AMR) among different microbes. In February, the World Health Organization presented a top 12 list of bacteria resistant to current antibiotics for which new drugs are desperately needed. After years of stagnancy, policy makers world wide have made the topic a high priority – and set up a large number of funding initiatives, especially for SMEs involved in R&D. Christopher Egerton-Warburton, Chair of the expert advisory board of the UK’s newly established Global AMR Innovation Fund (GAMRIF), argues for a multi-donor capital pool to address the estimated total funding need of €2bn. He lobbies for a ten-year perspective because drug developers “don’t need all the money on day one.” GAMRIF was set up by the British government with an initial capital base of £50m and is open for others to join. “Given my experience from the vaccine world, I strongly believe we should tame the bewildering and confusing AMR funding landscape and bundle all efforts into few strategic initiatives of high value instead of establishing too many stand-alone, fragmented funds,” emphasises Egerton-Warburton. Being aware of the society’s high hopes, he gives the AMR community some advice: “We need public money that behaves like private-sector venture capital. That would accelerate development.” Egerton-Waburton was the keynote speaker at the 10th Berlin Conference on Life Sciences in February. Attracted by this year’s topic, “Novel Antimicrobials,” the organisers, UK Department for International Trade and BIOCOM AG welcomed around 30 speakers and 130 attendees from European biotech and pharma companies. Drug developers, microbiologists, and investors discussed the growing need to efficiently combat AMR both at the speaker’s reception at the China Club and at the conference at the British Embassy in Berlin. The presenters argued that science and technology are not the only fields that will need to adress the spread of resistant bacteria.Beyond that, questions regarding funding, patenting, and pricing of new drugs, as well as antibiotics regulation and stewardship, have to be considered.
“In the antimicrobials space, there is a clear imbalance between high investment costs and a low return on investment,“ said Ute Kilger, partner at IP expert Boehmert & Boehmert (GER), opening the panel discussion about the bottlenecks in antimicrobials R&D. Moderator Peter West from the Academy of Infection Management (UK) added that the public appreciation of antibiotics has to improve, and Andrew Ullmann, Head of Infectious Diseases at the University clinical centre Würzburg (GER), advised drug developers to talk with clinical experts: “Often scientists don’t see the treasures they have in their pipeline until they discern the clinical context.“
During the conference, Peter Jackson – steering group chairman of UK’s newly established AMR Centre – gave an update on the first two CARB-X cycles. The AMR Centre in Alderley Park (UK) is a partner of the international initiative CARB-X – Combating Antibiotic Resistant Bacteria Biopharmaceutical Accelerator. The centre is one of two accelerators in the UK; the other two are US-based. CARB-X targets preclinical work, so most applicants will be SMEs. Over the first five years, the goal is to get a diverse range of 20 high-quality antibacterial products close to human testing. The US Biomedical Advanced Research Authority (BARDA) provides the CARB-X initiative up to US$250m. The AMR Centre is expected to receive up to US$100m in total. Adding its own financial resources, Jackson expects to be able to focus US$200m on a range of R&D projects. According to him, CARB-X received so far more than 360 companies worldwide expressed interest requesting over US$1bn in funding. “Currently, 11 projects are in triage at the AMR Centre. In March, we will announce the first selected projects,” Jackson told the audience.
The high relevance of SMEs was emphasised by the dozen companies that presented their new technologies and drug candidates during the conference. Some of them, such as AntibioTx from Denmark, reported successful progress in their antibiotic pipeline. NovaBiotics from Aberdeen (UK) stressed the need for a multi-targeted approach to combat AMR, developing therapeutic peptides as well as technologies to address biofilm resistance. “We are a small company with high ambitions,” CEO Deborah O’Neil said.
Both companies are members of the European consortium BEAM Alliance, which seeks to improve the regulatory, investment, and market viability of new products to fight antimicrobial resistance. Marie Petit, co-ordinator of the alliance, announced a new position paper by the European network: “In December, we established BEAM as an official association to more efficiently represent our more than 50 members. During 2017, we are going to precisely outline our recommendations.” In addition to the high need of appropriate regulatory mechanisms for novel antimicrobials, the SMEs called for flexible funding schemes. Petit: “The majority of innovation is done by SMEs, and we welcome all new funding initiatives. However, we should take care that the schemes are manageable for small companies.” The VC side showed willingness to invest in one to two antimicrobials companies per fund. "Regulatory environment has stabilised a lot. However, we need a promising exit strategy which is realistic within a ten-year frame,” said Olivier Litzka from Edmond de Rothschild (F).
The full range of entrepreneurial spirit and scientific excellence in the field became visible in the event’s start-up competition. Against Auspherix (UK), Quretech Bio (SE), Immunethep (P), and Omnix Medical (Israel), the Swiss start-up Juvabis stood out. The jury awarded Juvabis the first prize for its technology platform of next-generation aminoglycoside antibiotics that target the ribosome in Gram-positive and -negative bacteria.
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