Entries by Thomas Gabrielczyk

IO Biotech weighs strategic options months after FDA advises against melanoma vaccine filing

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Four months after the FDA advised it against filing for approval of its lead melanoma vaccine, IO Biotech is preparing for further restructuring. The Copenhagen-based biotech said yesterday that it is exploring strategic alternatives, including a merger, asset sale, business combination, or potential liquidation, and warned that it may need to implement additional workforce reductions and cost-cutting measures as the process unfolds.

Oxford-based cancer vaccine company Infinitopes closes $35 million seed round

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Infinitopes, a U.K. cancer vaccine biotech spun out of Cancer Research U.K. and the University of Oxford, has expanded its seed round to $35.1 million after a second close that added about $15.4 million to existing commitments. The financing was co-led by Octopus Ventures and new investor Amplify Bio. The company says the funds will support its upcoming first-in-human phase 1/2a VISTA trial of its lead therapeutic vaccine, ITOP1, aimed at reducing post-surgical recurrence in oesophageal cancer.

A changing playing field: Observations of the 2026 JP Morgan Healthcare Conference from a European perspective

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The Westin St. Francis lobby buzzed with its familiar January energy, a peculiar blend of jet lag, ambition, and the faint desperation of biotech CEOs clutching coffee cups like lifelines. This year’s JP Morgan Healthcare Conference arrived with a question hanging in the San Francisco fog: after years of what one executive called “nuclear winter,” were the capital markets finally thawing?

Takeover rumours at Qiagen fuel share price surge

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With the departure of the current CEO of diagnostics company Qiagen NV (Venlo, Netherlands/Hilden, Germany) and before a new chief executive has been identified and presented, there appears to be activity at senior management level, according to Bloomberg, around whether a sale of the company or the admission of a major strategic partner could be an alternative. These rumours have sent the share price sharply higher.

Heidelberg-based Exciva secures €51M to tackle agitation in Alzheimer’s care

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Alzheimer’s disease means memory loss for those affected. Beyond this, however, it is above all relatives and care staff who are impacted when the loss of cognitive abilities is accompanied by symptoms such as agitation, aggression, anxiety and depression, making home care impossible. This aspect of the disease is now gaining greater visibility through a major second financing round from EQT LifeScience, Gimv and Andera Partners with Exciva from Heidelberg.

Genmab and AbbVie’s epcoritamab fails in phase 3 lymphoma study

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Last week, Genmab and AbbVie hit a setback with epcoritamab, after the bispecific T-cell-engaging antibody failed to deliver a survival benefit in a phase 3 study in relapsed or refractory diffuse large B-cell lymphoma (DLBCL). The EPCORE DLBCL-1 trial missed its primary endpoint of overall survival, the partners said on Friday. While epcoritamab did slow disease progression and performed better across several secondary measures, the survival miss overshadows the readout.